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Moreover, it was demonstrated that activation was restricted not only to the luminal venous endothelium but also the endothelium in the vasa vasora of refluxing saphenous veins, as indicated by the upregulation of ICAM-1 [100]

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Signs suggesting secondary hypogonadism include low testosterone with low or inappropriately normal LH, intact testicular volume, no history of testicular injury or disease, and symptoms that developed gradually rather than suddenly

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