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HUBERMAN: Well, it's been shown to increase blood flow to a given area by virtue of increased angiogenesis
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doi: 10.1002/jnr.20248 4 BlakemoreW

Neither replaces the other

Design and synthesis of dually branched 5'-norcarbocyclic adenosine phosphonodiester analogue as a new anti-HIV prodrug

There were 3 deaths during the study, with 1.2% of patients affected