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Finally, given the pragmatic nature of the proposed trial, the decision was taken to include consecutive patients seeking medical help at the participating centres, thus ensuring the enrolment of subjects similar to those that would be seen in normal clinical practice

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Some prevention methods include: talking to a doctor about changing medications that are known to cause ulcers avoiding foods that can either trigger or worsen symptoms keeping the mouth clean with daily brushing and flossing avoiding triggers known to cause outbreaks in the past Mouth ulcers, also known as canker sores, are small, painful sores that develop inside the mouth