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Journal of Cosmetic Dermatology.

Thus, we investigated if promoting metabolic homeostasis by MOTS-c treatment could reverse age-dependent decline in physical capacity

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In further embodiments, the tonicity agents are present in an amount as to provide a final osmolality of an otic formulation or composition of about 100 mOsm/kg to about 500 mOsm/kg, from about 200 mOsm/kg to about 400 mOsm/kg, from about 250 mOsm/kg to about 350 mOsm/kg or from about 280 mOsm/kg to about 320 mOsm/kg

This should be weighed against the potential benefits[80,81]