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Using a streptozotocin-induced diabetic mouse model, the researchers demonstrated that systemic administration of BHB, an endogenous HCAR2 ligand, significantly reduced retinal endoplasmic reticulum (ER) stress and NLRP3 inflammasome activation, both of which are key contributors to diabetic retinopathy

Dose ranges come from allometric scaling (using a math formula to translate a mouse mg/kg dose into a human dose) and from research community use

Huisjes, R

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It is useful to share insightful information on Ferredoxin Glutathione Reductase This PPT slide can be easily accessed in standard screen and widescreen aspect ratios

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