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Activation of P2X7 promotes astrocyte differentiation, and astrocytes can secrete D-serine, a co-agonist at NMDARs, to enhance both homo- and heterosynaptic long-term potentiation (LTP (146))

An additional technique is peripheral arterial tonometry (PAT), a non-invasive diagnostic test that measures changes in blood volume in fingers or toes

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For example, in a rat model of CHI induced by permanent bilateral common carotid artery occlusion (2VO), GA significantly restored spatial memory, increased time spent in the target quadrant, and improved memory consolidation (Sarkaki et al., 2014)

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The -chain aggregates could produce reactive oxygen species, leading to oxidative stressinduced red blood cell (RBC) senescence [3].The basic clinical symptom of -thalassemia major is chronic anemia, which reduces the number of RBCs and hemoglobin (Hb) content, resulted from hemolysis and a deficiency in Hb production When RBCs are destroyed within the vascular compartment, Hb escapes into the plasma, dimerizes, and is rapidly bound by the serum protein haptoglobin (Hp)