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Specific anti-SARS-CoV-2 properties of vitamin A include: Supports the innate and acquired immune system Regulates T-cells Increases lymphocytopoiesis, or the generation of new lymphocytes (T cells and B cells), that are essential to adaptive immunity Has anti-oxidant and anti-inflammatory effects Regulates surfactant protein gene expression, which may then reduce the impact of SARS-CoV-2 infection on the ability to breathe Plays a crucial role in the formation of epithelial cells and improves the integrity of epithelial tissues (those of the respiratory, gastrointestinal and urogenital tracts) An estimated 75% of adults in the United States do not meet the recommended intakes for vitamin A

This bidirectional behavior highlights a critical context dependence in antioxidant biology, where the same metabolite may either suppress or amplify ferroptotic stress depending on iron availability and intracellular redox flux