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The differing toxicities of ionizable organic compounds at different pH values can be attributed to the distinct permeabilities of the existing species (i.e., neutral and ionized forms) because neutral species can permeate biomembranes and become trapped in cells faster than the corresponding charged species, resulting in distinct differences in the internal concentrations

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Distributionlevodopa predominantly travels unbound in plasma and enters tissues readily, while polyphenols often bind to albumin or are sequestered within specific tissues [106]

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Testing programs are administered by national anti-doping organizations and international federation programs

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