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Clinical trials and meta-analyses indicate improvements in ventricular function and reductions in mortality, arrhythmias, and angina

Whether these discrepancies arise from insufficient subtype selectivity of compounds with activity at TRP channels, compensatory expression changes in knockout animals, or difference between animal models, remains to be determined

For example, the LC-MS/MS method mentioned in the study can simultaneously quantify up to 30 carnitines and their analogs, covering the range of C0 to C18, and significantly improves the accuracy and throughput of quantitative analysis

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Decreases in IENFD correlated with altered QST, particularly for mechanical sensation, in patients with chronic CIPN after docetaxol or oxaliplatin [55]: After vincristine treatment, myelinated A-beta fibres were affected first, followed by A-delta and c fibres[29]