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When a bone is broken, our body immediately reacts by mounting two responses: one at the cellular level where thousands of microscopic cells rush to repair the damaged tissue, and another at the whole-body level where our immune system and musculoskeletal system work together to fix the injury

We noted that the lung to body weight ratio was indeed elevated in AA-exposed mice compared to PBS and melatonin-only controls, however the extent of this increase was substantially reduced in those mice which received melatonin alongside AA ( Figure 1B )

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Specifically, the cells basal OCR, maximal OCR, and spare respiratory capacity were not impacted after 24 hours of incubation with 1 M CB-839 ( Supplemental Figure 6 )

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