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Cloning and characterization of a cytosolic isoform of triosephosphate isomerase developmentally regulated in potato leaves

Handb Exp Pharmacol [Internet]

Figure 2 Pathological Effect Caused by PDH Imbalance As a critical node in metabolic regulation, PDHC converts pyruvate to acetyl-CoA in mitochondria, and its inhibition leads to early metabolic reprogramming in response to sepsis, resulting in the accumulation of lactic acid, the aggravation of inflammation, the remodeling of TCA cycle, and the disorder of lipid metabolism, and the consequence of lower ATP synthesis relative to ATP demand

& Fujii, J

Indication #2: Prevention of HRS in patients with SBP Prevention of HRS in patients with SBP Indication #2: In the early 1990s, it was shown that 1/3rd of inpatients with SBP developed renal impairment