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42 , 162 , 163 , 164 , 165 IMiDs have also demonstrated improvements in daratumumabmediated ADCC in lenalidomiderefractory MM cells, while pomalidomide enhances isatuximabinduced ADCC in vitro and in vivo

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Gruneberg D, Montellano FA, Plaschke K, Li L, Marti HH, Kunze R (2016) Neuronal prolyl-4-hydroxylase 2 deficiency improves cognitive abilities in a murine model of cerebral hypoperfusion

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It also interacts with the F-actin cytoskeleton in fibroblasts, improving cell spreading and migration needed for wound closure
