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The two signals are not balanced

Neurofibromatosis Type 1 Alternative Splicing Is a Key Regulator of Ras Signaling in Neurons

Knowing why it happens is important for treatment

doi: 10.1089/ars.2015.6369 82 GuoWLiDYouYLiWHuBZhangSet al

found that the level of OS increased from menstrual day 1 and reached a peak around day 15 (late proliferative/early secretory phase) and then moderately decreased, which was coincident with significantly increased vascular density in the late secretory phase

This leaves your cells more vulnerable to damage
