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This is partially accomplished by increasing the activity of mitochondrial transcription factors such as forkhead box, class O (FOXO) and antioxidant response element (ARE), which is mediated by the master regulator of antioxidant and cytoprotective systems, nuclear factor erythroid-2-related factor (Nrf2) [86,87,88]

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10.1016/j.bbagen.2018.04.011 BBA Gen

infection prompts the formation of giant cells, which are implicated in immune evasion by possibly suppressing the hosts immune response to prevent pathogen clearance