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All family members share a modular structure consisting of an NH 2 -terminal sequence responsible for oligomerization of TNC, TNR, and possibly TNX

When ROCK is inhibited with Y-27632, it causes a redistribution of F-actin, leading to decreased nuclear localization of YAP and reduced expression of Cgtf and Cyr61

Ethanol, isopropanol, or other alcohols denature peptide structures on contact

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The theoretical basis is that macrophage polarization imbalance alone is sufficient to induce PAH (141), demonstrating the therapeutic potential of this approach

JD: Conceptualization, Supervision, Validation, Writing original draft, Writing review & editing