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Researchers using murine small-cell lung cancer cells that spontaneously transdifferentiated from a non-neuroendocrine (non-NE) state into a neuroendocrine (NE) state discovered that the cells in the non-NE state were ferroptosis sensitive 137

V., Leitner, W

Inhibition of system Xc(-) leads to compensatory upregulation of SLC7A1L transcription (12), and SLC7A11 transcriptional upregulation was found in salazopyridine- and erastin-induced ferroptosis models

Targeted Delivery of Antioxidants via NDDS Targeted drug delivery is of great interest for selectively carrying the active pharmaceutical ingredients (APIs) to the site of action for a prolonged period at a therapeutically adequate amount

Oxidative stress, compressive overload, nutrient stress, enhanced inflammation, and other factors can act on these parts and stimulate aberrant cellular responses and progressive structural deficiency, leading to disc degeneration 32

In the immune response reaction, innate kick-starts within 24 hours after transplantation ( Figure 1 )