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As a result, people face fatigue, weakness, dizziness, and shortness of breath

The potential dangers may include unforeseen side effects or interactions as well as a lack of standardized dosing guidelines
In rodents and in humans genetic evidence demonstrates that the loss of SIM1 causes hyperphagic obesity in addition to causing resistance to the anorectic effects of melanocortins [68,69]

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While safety was established, efficacy for weight loss did not meet clinical trial success criteria
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