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Your arm may feel heavy, itchy or slightly bruised at the injection site but these side effects generally pass quickly

recommended that all patients on long-term metformin therapy should be tested for serum B12 deficiency annually [80]

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When the conversion of propionyl-CoA to succinyl-CoA in the mitochondria fails due to Vitamin B 12 deficiency, elevated blood levels of methylmalonic acid (MMA) occur

It works through a different mechanism (fat oxidation via beta-3 adrenergic receptors, not appetite suppression), and that mechanism produces gradual, subtle changes