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For example, the UGT1A4*3 variant has been shown to affect the metabolism of olanzapine, an antipsychotic drug metabolised to four oxidised metabolites and two N -glucuronides

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This is primarily through the secretion of cytokines associated with type_2 IRs (Hendel et al

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It was engineered to cross the blood-brain barrier and increase BDNF a key molecule in brain plasticity and memory