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The UPR consists of three main signaling pathways, PERK, IRE-1, and ATF6., that normally bound by a chaperone called Grp78 and are inactive

doi: 10.1038/nm1477

Constipation-predominant irritable bowel syndrome females have normal colonic barrier and secretory function

Different studies and clinical trials have shown different results, which creates a dilemma for researchers