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Clinical therapy of targeting ferroptosis in human diseases Numerous preclinical studies have demonstrated that iron acts as a potent pro-oxidant, contributing to the development and progression of tumors, central nervous system diseases, metabolic diseases, autoimmune diseases, and cardiovascular diseases through the production of highly reactive and cytotoxic free radicals

Considering the nature of the neuropsychiatric manifestations, compounds able to modulate the underlying molecular mechanisms and biochemical pathways can be considered

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A significant decrease in IL-8 levels in severe sepsis patients treated with NAC, while NAC had no effect on IL-6 levels as reported in that study[26]

In infectious diseases, antibiotic therapy has been so successful because it targets molecules of the pathogens that are highly distinct from humans, thus achieving very manageable adverse effects

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