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The initial model was refined alternating cycles of manual model building in COOT 58,59 and automatic refinement using Phenix 60 v.1.19.2

S., Shah J

The graphic below does more justice to the complexity of the gut-brain axis compared to what Ive oversimplified

[DOI] [PubMed] [Google Scholar] Hui L

Specifically, they utilized spherical COF called TpBD, synthesized from 1,3,5-triformylphloroglucinol (Tp) and benzidine (BD), which demonstrated unique morphology, strong optical absorption properties, and excellent chemical and thermal stability