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Moreover, despite extensive research into the molecular mechanisms underlying the observed benefits of SCT, a consensus on how stem cells precisely contribute to these effects, even in animal models, remains elusive [152]

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With an increase in oxidative stress, Nrf2 is released and translocates to the nucleus, where it binds and activates the ARE and upregulates several genes associated with glutathione synthesis and antioxidant defense (Figure 2) [45,48]

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