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Initiate supplementation with oral folic acid and intramuscular vitamin B 12 prior to the first dose of pemetrexed

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A 2008 study found that your body actually only absorbs 1.3 percent of a 1,000-mcg dose and 2 percent of a 500-mcg dose

Nowadays we can understand that sex, age, race and ethnicity, in the context of socioeconomic status and lifestyle (tobacco, alcohol, education, physical exercise, unbalanced diet, etc.) impacts directly in its prevalence [7, 8, 10, 27 36]