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The combination shows approximately 15-18% weight loss, falling between semaglutide alone and tirzepatide

Its about matching treatment to the cause of the deficiency

[36] The MMACHC gene product catalyzes the decyanation of cyanocobalamin as well as the dealkylation of alkylcobalamins including methylcobalamin and adenosylcobalamin

Whilst these compounds have established biochemical functions, there is no robust randomised controlled trial evidence for clinically meaningful weight loss or fat reduction in replete individuals

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