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Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases

Baseline inflammation

These disruptions may influence glutamate transporter expression and function indirectly, as calcium-dependent pathways, such as those mediated by protein PKC, calcium/calmodulin-dependent protein CaMKII, and calcineurin, play critical roles in regulating EAAT trafficking and activity [77,94]

A correlation of XDH and GSS genes' expression and poor prognosis among breast cancer patients treated with tamoxifen was seen

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Evidence of neuroinflammation includes activated microglia and astrocytes found in post-mortem brain tissue (Pardo et al
