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*Correspondence: Xi Cheng, [email protected] Niu, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Dementia and Neurodegenerative Diseases, a section of the journal Frontiers in Neurology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

a,b , Representation of the stationary points calculated with ONIOM(B97X-D/6-311 + G(2d,p):ff14SB,gaff2,TIP3P) G(d):ff14SB,gaff2,TIP3P) for the Pt GSTF8-catalysed deprotonation-protonation reaction: flavan-3-on-4-ol ( 7 ), transition state for deprotonation ( 7-TS ), deprotonation product ( 8-enolate ) and cyanidin ( 8-B4 ) bound to the wild-type enzyme ( a ) and the C13S variant ( b )

However, 10 of 41 patients were unable to complete the protocol because of side effects (cough, wheezing or worsened dyspnea), and two of the patients who completed the trial acquired tobramycin-resistant Pseudomonas species

A link between benzyl isothiocyanate induced cell cycle arrest and apoptosis: Involvement of mitogen activated protein kinases in the Bcl2 phosphorylation

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5FAD, mice, 5 familial AD, mutations mice