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7 Generally, this is recommended for patients with tophi, radiographic damage attributable to gout, or frequent flares (2 or more per year)
The burden is highest during weeks 9-24 when both are escalating

Because Vitamin B12 requires proper digestive absorption, some individuals choose IV delivery for direct availability in the bloodstream, which removes dependence on gastrointestinal uptake

Inflamed endothelial cells may also have changes in the expression or distribution of receptors, e.g., insulin receptors, which can affect RMT

That makes it older than Stonehenge, its more famous counterpart
