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Because this study was a first-in-human phase 1 trial, we used the standard 3 + 3 design, which is one of the most used designs due to its simplicity of execution and robustness in phase 1 clinical trials 12

In view of the preponderance of neurological dysfunction associated with a CoQ10 deficiency, it would appear judicious to assess cerebral CoQ10 status in patients suspected to have this deficit

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This "lipid bilayer" (a double layer of fat molecules) shields the glutathione as it passes through the digestive tract

Protease-antiprotease imbalance contributes to COPD pathogenesis, evidenced by elevated matrix metalloproteinases (MMP-9, MMP-12) and tissue inhibitors (TIMP-1) in BAL (174)

[DOI] [PubMed] [Google Scholar] 212.Dejanovic B, et al