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Melatonin supplementation alone, though, wasnt enough to return the AD mice to normal control levels, but the improvements were significant.[ref][ref][ref][ref] Another study using a mouse model of AD found that melatonin reduced the signs of Alzheimers, including cognitive deficits

Cagrilintide was tested in shorter-duration studies (26 weeks) with titration protocols that minimised dropout, while tesofensine trials ran longer (2452 weeks) but saw higher discontinuation rates due to stimulant-like side effects

Levkovitz Y, Mendlovich S, Riwkes S, Braw Y, Levkovitch-Verbin H, Gal G, et al