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Ceyhan GO, Bergmann F, Kadihasanoglu M, Altintas B, Demir IE, Hinz U, et al

Amyloid -peptide in patients with Alzheimers disease (AD) has been shown to downregulate the functional activity of glutamate transporters [165]

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The primary therapeutic effect of curcumin is the promotion of macrophage polarization to the M2 phenotype by use of interleukin-4 and interleukin-13, which regulate the role of macrophages in inflammatory signaling (Gao et al., 2015)

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Notably, ADO has been shown to target regulators of G-protein signaling (RGS) proteins, which attenuate G-protein signaling by enhancing G-coupled GTP hydrolysis, and IL-32, a proinflammatory cytokine