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Supplementary information ESM 1 (download DOCX (DOCX 1210 kb) Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

Some studies indicate that caffeine may interact with AED, potentially reducing their effectiveness, especially topiramate[229]

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Weak Immune System A strong immune system can reduce the incidence and severity of sickness