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Description

Treatment of mice bearing trastuzumab-resistant tumors or PDX of resistant HER2+ mammary carcinomas with abemaciclib restored the sensitivity of tumors to HER2-inhibitors, and inhibited tumor cell proliferation

This is consistent with both being partially produced by beneficial intestinal bacteria

Safety Toxicity Few side effects have been noted in adults taking supplements of less than 2,000 mg of -tocopherol daily (either natural or synthetic vitamin E)

Larsson, K

This study was supported by the Guangdong Basic and Applied Basic Research Foundation (2024A1515011821), the Science and Technology Projects in Guangzhou (2025A03J4226), and the Longgang District Science and Technology Innovation Bureau Project (LGKCYLWS 2024-9)