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Contents Historical background Main function Sites of the pentose phosphate pathway Oxidative phase of the pentose phosphate pathway Non-oxidative phase of the pentose phosphate pathway The cells need for NADPH, ribose 5-phosphate, and ATP References Historical background The first evidence of the pentose phosphate pathway emerged in the 1930s through the work of Otto Warburg , who received the Nobel Prize in Physiology or Medicine in 1931 for his work on cellular metabolism and respiratory enzymes