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Studies have found that ferroptosis inducers decrease GPX4 activity and enhance intracellular lipid peroxidation, further exacerbating the progression of renal injury and fibrosis

This initiates a vicious cycle of oxidized membrane receptors, signaling molecules, transcription factors, and epigenetic transcriptional regulators (420, 421)

Then cells were cultured in serum-free RPMI-1640 medium containing either Bi 2 S 3 (Bi: 60 g mL 1 ) or Bi 2 S 3 -3BP (Bi: 60 g mL 1 , 3BP: 10 g mL 1 ) for another 6 h, and the system was sealed or not sealed with sealant

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