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Mohammed I, Hollenberg MD, Ding H, Triggle CR (2021) A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan

Among typical behaviors assessed in mice and rats, directly related to the core symptoms of autism, are deficits in social interaction (i.e., three-chamber social approach paradigm), deficits in communication (i.e., analysis of ultrasonic vocalizations), increased repetitive/stereotyped motor behaviors (i.e., self-grooming or marble burying), and persistence on sameness and restricted interests (i.e., perseveration in the T maze or water maze) [23,24]

Copper is only required in trace amounts by the body, and too much copper buildup could theoretically cause nausea, abdominal pain, tiredness, liver damage, and neurological effects

Fox H, Bond B, Parslow T

In parallel, zinc rapidly induces the expression and activation of lysosomal proteases cathepsin B and D, through early V-ATPase-dependent acidification and later TFEB-mediated transcription

It can also be added to food as fortifying agents, flavor intensifier or stabilizer