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It is diagnosed according to the Canadian consensus criteria, at least 6 months after onset when the following symptoms are present: fatigue, post-exertional malaise with a recovery period of at least 24 h, sleep dysfunction, pain, at least two neurological/neurocognitive symptoms and at least two symptoms involving the autonomic, neuroendocrine or immune system [19]

Loomba, R

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Ramai D, Dang-Ho KP, Lewis C, Fields PJ, Ofosu A, Barakat M, Aamar A, Ofori E, Lai J, Lanke G, Dhaliwal A, Reddy M, Gasperino J

Lasley, BL

However, very high doses taken for extended periods may increase the risk of mild gastrointestinal symptoms