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Systematically decipher the functional mechanisms of non-canonical defense pathways (FSP1-coenzyme Q10, GCH1-BH4, and DHODH) in periodontal tissues (129131), validate their regulatory roles through gain-of-function and loss-of-function experiments, and develop targeted agonists or lipid droplet-directed nanomedicines for therapeutic intervention (132134)

Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting

The decreased virulence of the sod1 strain may be due to increased susceptibility to oxygen radicals within macrophages, while other antioxidant defense systems in can compensate for the loss of Cu-Zn SOD in vivo [76]

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4, 124133 10.1038/ncb744 [DOI] [PubMed] [Google Scholar] 110.Yoshino, A., Setty, S.R.G., Poynton, C., Whiteman, E.L., Saint-Pol, A., Burd, C.G.et al

Schwann cell C5ar1 co-opts inflammasome nlrp1 to sustain pain in a mouse model of endometriosis