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In contrast, M2 polarized tumor-associated macrophages (TAMs), are associated with worse outcomes as they cause angiogenesis, ECM degradation, and metastasis (106)

256 , 257 In pancreatic cancer, the ESPAC-4 trial showed that aspirin significantly improved survival, with median DFS and OS increasing to 17.9 and 42.4 months, respectively, compared to non-users

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doi: 10.1002/sim.7221 35

Arboviral infections including Chikungunya infection is managed by supportive measures
