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In pancreatic -cells, prohormone convertase 2 action leads to the release of glucagon
Studies have shown that 1,25(OH)D enhances intercellular adhesion among keratinocytes by upregulating E-cadherin expression and inhibiting -catenin nuclear translocation, thereby stabilizing adherens junction complexes and reinforcing the integrity of tight junctions in the epidermis [222]
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These properties make it unlikely to enter the general circulation to cause bad outcomes unless the intake is excessive
10.1111/j.1582-4934.2010.01065.x 5 Al-SadiR.GuoS.DokladnyK.SmithM
doi: 10.1016/j.jdiacomp.2014.04.011
