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Various cellular components found in sputum, such as neutrophils [25], lymphocyte subsets (CD8-IL4/CD8-IFN ratio) [26], and cytotoxic CD56 cells (1414 biological lytic activity) [27], inflammatory mediators including prostaglandin E2 (PGE2) [28], chemokines including C-X-C motif chemokine ligand (CXCL) 9, CXCL10, CXCL11, CC motif chemokine (CCL) 5, and CCL3 [29, 30], proteases including matrix metalloproteinase-2 (MMP-2) [28], oxidative stress-related substances including peroxynitrite inhibitory activity and 8-iso-PGF2 [31, 32], as well as other molecules like VEGF [23], osteoprotegerin (OPG) [33], fatty acid-binding protein 4 (FABP4) [34], and microRNAs (hsa-let-7c, hsa-miR-34b, hsa-miR-34c, hsa-miR-125a-5p, hsa-miR-30a-3p, and hsa-miR-30e-3p) [35] have demonstrated significant correlations with the severity of COPD

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[260] He was scheduled to film the sequels to The Matrix the following spring, but sought "peace and time", according to friend Bret Domrose of Dogstar

Post-mortem studies of ASD patient brains have revealed downregulation of both GAD65 and GAD67 in the superior temporal gyrus, potentially disrupting normal GABA synthesis in the brains of individuals with ASD (38)

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