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Description

Total SAC content in the blood of volunteers at T max is about 450 g (content on T max , 23 ng/mL plasma

Acetate: friend or foe

Its inhibition (using CPI613) leads to the accumulation of 2hydroxyglutaric acid (2HG)

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NAC (75 or 100 mg/kg/dose) was given by nasogastric (NG) administration every 6 h for 4 days, then combined with taVNS paired with 2 daily feeds for another 14 days

The next decade will be pivotal in translating accumulating clinical and preclinical findings into meaningful therapies that can prevent or reverse the course of DN, ultimately improving outcomes for millions of patients