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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 10% by weight of the silicon dioxide

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We demonstrated for the first time that oxidative stress induced a significant loss of mitochondrial mass by decreasing mitochondrial number and volume density in the ONH astrocytes

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In our implementation, TabPFN was used in its standard pre-trained inference mode, while the task-specific training data were supplied through the fit procedure as contextual reference rather than through dataset-specific gradient-based fine-tuning of model weights

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