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The quality assessment revealed that most studies had a low risk of bias or some concerns in various areas

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Each goal aligns with a different level of complexity and resource use, which is why pricing varies

Accordingly, the administration of Ca 2+ /Mg 2+ prior to oxaliplatin infusion has been evaluated in several clinical trials as a strategy to prevent development of CIPN, although a consistent clinical benefit is unfortunately not apparent (Jordan et al., 2016)

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Terra MF, Garca-Arvalo M, Avelino TM, Degaki KY, de Carvalho M, Torres FR, Saito A, Figueira ACM