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Untreated and undiagnosed cases can result in sudden death

2008 Mar;51(3):784-90

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CVS has significant diagnostic challenges, given that there is no specific test for confirming its presence

Complexed CRP was previously shown to be an effective activator of the complement through C1q binding, and it may modulate pathophysiologic actions mediated via cryoglobulins in vivo since a previous case report described the formation of a complex between a monoclonal IgA with cryolabile properties and CRP

& Harrell, T