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PMID 17932121

2011;94((Suppl

Elevated levels of -hydroxybutyrate (-HB) bind to the NLRP3 inflammasome, inhibiting its activity and thereby reducing the release of the inflammatory factors IL-1 and IL-18, slowing myocardial fibrosis and promoting the recovery of the ejection fraction during heart failure progression ( However, acetoacetic acid (AcAc) is considered to have pro-inflammatory effects

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Mitochondrial function is required for extracellular ATP-induced NLRP3= inflammasome activation