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sFRP1 is also downregulated via multiple miRNAs in breast cancer (Yang et al., 2015)
It also has potent antioxidant and anti-inflammatory effects, reducing oxidative stress in gingival tissue

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WHO Report

127 RamakrishnanV.XuB.AkersJ.NguyenT.MaJ.DhawanS.et al (2020)

Which is part of why a peptide first pulled out of human plasma back in 1973 still keeps turning up in anti-aging conversations five decades later
