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The following databases were searched: Ovid MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, Ovid Embase, Wiley Cochrane, EBSCO Cumulative Index to Nursing & Allied Health Literature (CINAHL), and Centre for Reviews and Dissemination/International Agency for Health Technology Assessment

Studies have shown that enhancing insulin sensitivity through supplementation with insulin-sensitizing additives such as chromium, thiazolidinediones, or lipoic acid can improve animal performance during heat stress (Ranganathan et al., 2006

These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them

However, aggregate data and covariates of interest (eg, sex, disease severity) are not consistently reported across randomised clinical trials (RCTs).6 The use of individual patient data (IPD) has several advantages, such as it allows for the exploration of the relationship between treatment effects and patient-level characteristics, and it overcomes restrictions in using the information reported in the publication among others

It may result from vascular injury during graft surgery or the hosts immune system attacking the graft tissue