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Trends Biochem Sci 2004, 29, (5), 243-9, 10.1016/j.tibs.2004.03.007
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Mascaraque et al

The prolyl hydroxylase domain-containing protein (PHD)HIF hypoxia-inducible factor (HIF) pathway is the most extensively studied response mechanism to hypoxia, with its dysfunction linked to various diseases (Schofield and Ratcliffe, 2004)

USA 94 , 20312035 (1997)

Chronic Obstructive Pulmonary Disease (COPD) - Inflammation in the airways leads to the constriction and tissue damage seen in chronic respiratory conditions