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DOI: 10.1016/j.jdiacomp.2007.10.003 57

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KPV increases blood flow by activating endothelial nitric oxide synthase (eNOS), which increases the generation of nitric oxide, a potent vasodilator that relaxes blood vessels and reduces blood pressure

Despite the extreme sequence divergence between the GST classes the overall structures of the enzymes are remarkably similar (Figure 4)

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Its also, frankly, where things can go catastrophically wrong